Mizuho's Home Page




Hasegawa M, Yada S, Liu MZ, Kamada N, Muñoz-Planillo R, Do N, Núñez G, Inohara N. Interleukin-22 Regulates the Complement System to Promote Resistance against Pathobionts after Pathogen-Induced Intestinal Damage. Immunity (2014) 41(4):620-32.

Nakamura Y, Oscherwitz J, Cease KB, Chan SM, Muñoz-Planillo R, Hasegawa M, Villaruz AE, Cheung GY, McGavin MJ, Travers JB, Otto M, Inohara N, Núñez G. Staphylococcus d-toxin induces allergic skin disease by activating mast cells. Nature (2013) 503:397-401

Jiao Y, Darzi Y, Tawaratsumida K, Marchesan JT, Hasegawa M, Moon H, Chen GY, Núñez G, Giannobile WV, Raes J, Inohara N. Induction of bone loss by pathobiont-mediated nod1 signaling in the oral cavity. Cell Host Microbe. (2013) 13:595-601.

Wang N, Huang CY, Hasegawa M, Inohara N, Fujimoto Y, Fukase K. Glycan Sequence-Dependent Nod2 Activation Investigated by Using a Chemically Synthesized Bacterial Peptidoglycan Fragment Library. Chembiochem. (2013) 2013 14:482-428.

Hasegawa M, Kamada N, Jiao Y, Liu MZ, Nunez G, Inohara N.
Protective Role of Commensals against Clostridium difficile Infection via an IL-1beta-Mediated Positive-Feedback Loop.
J Immunol. 2012 189:3085-91

Hasegawa M, Yamazaki T, Kamada N, Tawaratsumida K, Kim YG, Nunez G, Inohara N.
Nucleotide-Binding Oligomerization Domain 1 Mediates Recognition of Clostridium difficile and Induces Neutrophil Recruitment and Protection against the Pathogen.
J Immunol. 2011 Apr 15;186(8):4872-80.

Piao JH, Hasegawa M, Heissig B, Hattori K, Takeda K, Iwakura Y, Okumura K, Inohara N, Nakano H.
Tumor necrosis factor receptor-associated factor (Traf)2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease.
J Biol Chem. 2011 May 20;286(20):17879-88.

Pradipta AR, Fujimoto Y, Hasegawa M, Inohara N, Fukase K.
Characterization of natural human nucleotide-binding oligomerization domain protein 1 (NOD1) ligands from bacterial culture supernatant for elucidation of immune modulators in the environment.
J Biol Chem. 2010 Jul 30;285(31):23607-13.

Botero TM, Son JS, Vodopyanov D, Hasegawa M, Shelburne CE, Nor JE
MAPK signaling is required for LPS-induced VEGF in pulp stem cells.
J Dent Res. 2010 Mar;89(3):264-9.

Hasegawa M, Osaka T, Tawaratsumida K, Yamazaki T, Tada H, Chen GY, Tsuneda S, Nunez G, Inohara N.
Transitions in Oral and Intestinal Microflora Composition and Innate Immune Receptor-Dependent Stimulation during Mouse Development.
Infect Immun. 2010 78 (2) 639-50

Hasegawa M
, Imamura R, Motani K, Nishiuchi T, Matsumoto N, Kinoshita T, Suda T.
Mechanism and repertoire of ASC-mediated gene expression.
J Immunol. 2009 Jun 15;182(12):7655-62.

Kawasaki A, Karasudani Y, Otsuka Y, Hasegawa M, Inohara N, Fujimoto Y, Fukase K.
Synthesis of Diaminopimelic Acid Containing Peptidoglycan Fragments and Tracheal Cytotoxin (TCT) and Investigation of Their Biological Functions.
Chemistry. 2008;14(33):10318-30.

Srimathi T, Robbins SL, Dubas RL, Hasegawa M, Inohara N, Park YC.
Monomer/Dimer Transition of the Caspase-Recruitment Domain of Human Nod1.

Biochemistry. 2008 Feb 5;47(5):1319-25.

Hasegawa M, Fujimoto Y, Lucas PC, Nakano H, Fukase K, Nunez G, Inohara N.
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation.
EMBO J. 2008 Jan 23;27(2):373-83.

Matsumoto M, Yaginuma K, Igarashi A, Imura M, Hasegawa M, Iwabuchi K, Date T, Mori T, Ishizaki K, Yamashita K, Inobe M, Matsunaga T.
Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells.
J Cell Sci. 2007 Mar 15;120(Pt 6):1104-12.

Hasegawa M, Kawasaki A, Yang K, Fujimoto Y, Masumoto J, Breukink E, Nunez G, Fukase K, Inohara N
A role of lipophilic peptidoglycan-related molecules in induction of Nod1-mediated immune responses.
J Biol Chem. 2007 Apr 20;282(16):11757-64.

Hasegawa M, Kawase K, Inohara N, Imamura R, Yeh WC, Kinoshita T, Suda T.
Mechanism of ASC-mediated apoptosis: Bid-dependent apoptosis in type II cells.
Oncogene. 2007 Mar 15;26(12):1748-56.

Park JH, Kim YG, McDonald C, Kanneganti TD, Hasegawa M, Body-Malapel M, Inohara N, Nunez G
RICK/RIP2 Mediates Innate Immune Responses Induced through Nod1 and Nod2 but Not TLRs.
J Immunol. 2007 Feb 15;178(4):2380-6.

Kinoshita T, Kondoh C, Hasegawa M, Imamura R, Suda T.
Fas-associated factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1.
Int Immunol. 2006 Dec;18(12):1701-6.

Hasegawa M, Yang K, Hashimoto M, Park JH, Fujimoto Y, Nunez G, Fukase K, and Inohara N.
Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments.
J. Biol. Chem. 2006 Sep 29;281(39):29054-63

Masumoto J, Kobayashi H, Nakamura T, Kaneko Y, Ota H, Hasegawa M, Kobayashi Y, Suzuki T, Matsuda K, Sano K, Katsuyama T, Inohara N
Regulation of the ASC expression in response to LPS stimulation is related to IL-8 secretion in the human intestinal mucosa.
Biochem Biophys Res Commun. 2006 Aug 4;346(3):968-73.

Nishito Y, Hasegawa M, Inohara N, Nunez G.
MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis.
Biochem J.
2006 Jun 15;396(3):411-7

Masumoto J, Yang K, Varambally S, Hasegawa M, Tomlins SA, Qiu S, Fujimoto Y, Kawasaki A, Foster SJ, Horie Y, Mak TW, Nunez G, Chinnaiyan AM, Fukase K, Inohara N.
Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo.
J Exp Med.2006 Jan 23;203(1):203-13

Kinoshita T, Wang Y, Hasegawa M, Imamura R, Suda T.
PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion.
J Biol Chem. 2005 Jun 10;280(23):21720-5.

Hasegawa M, Imamura R, Kinoshita T, Matsumoto N, Masumoto J, Inohara N, Suda T.
ASC-mediated NF-kappa B activation leading to IL-8 production requires caspase-8 and Is inhibited by CLARP.
J Biol Chem. 2005 Apr 15;280(15):15122-30.

Imamura R, Konaka K, Matsumoto N, Hasegawa M, Fukui M, Mukaida N, Kinoshita T, Suda T.
Fas ligand induces cell-autonomous NF-kappaB activation and interleukin-8 production by a mechanism distinct from that of tumor necrosis factor-alpha.
J Biol Chem. 2004 Nov 5;279(45):46415-23.

Wang Y, Hasegawa M, Imamura R, Kinoshita T, Kondo C, Konaka K, Suda T.
PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1.
Int Immunol. 2004 Jun;16(6):777-86.


ライフサイエンス 新着論文レビュー  2014年10月

Hasegawa M, Inohara N. Regulation of the gut microbiota by the mucosal immune system in mice.
Int Immunol. (2014) 26:481-7. 

Jiao Y, Hasegawa M, Inohara N. Emerging roles of immunostimulatory oral bacteria in periodontitis development. 
Trends Microbiol. (2014) 22:157-63.  

長谷川 瑞穂
, 猪原 直弘
実験医学(羊土社)Vol.30 No.11 2012年7月号

増本 純也, 長谷川 瑞穂, 猪原 直弘
炎症と免疫(先端医学社)Vol.16 No.5 2008年9月号

増本 純也, 長谷川 瑞穂, 猪原 直弘
日本臨床免疫学会会誌 Vol. 30: 68-77 (2007) .

細胞工学(秀潤社) Vol.25 No.37 2006年7月号

分子消化器病(先端医学社) 2006年6月号

「Nod2 用語解説」 
分子細胞治療(先端医学社) 2006年2月号

受賞 Award

第4回 高安賞 2005年